Services / Bioinformatics

Bioinformatics

Contract Research Services

We offer many analysis services, and our customizable services include annotating correlations between genes, proteins, diseases. The annotations are generated from our proprietary curated knowledge base containing information extracted from over 60 public data sets, original in-house data, and a collection of over 75 million non-redundant chemical compounds.


DATA SELECTION, DATA STORAGE, DATA ANALYSIS & DATA INTERPRETATION

Bio Re Inventors providing wide range of bioinformatics services on both genome, proteome and transcriptome. Our services include:
 
• Sequence Analysis: BLAST, FASTA  
• Functional gene annotation and enrichment  
• Phylogenetic analysis: Multiple sequence analysis  
• Gene Ontology and pathway Analysis  
• Comparative genomics  
• Gene and protein structure prediction  
• Primer Design and ORF's Prediction

Bio Re Inventors has 2 years of experience on drug discovery and development, database development, customized software solutions, and tools development and analysis. Our group of experts providing services on molecular docking, Pharmacophore and pharmacokinetic analysis, pathway identification etc...

100% Accuracy Results | Highly Confidential

Custom Designed Applications on Drug Discovery

WORK WITH US

Natural Compounds
Synthetic Compounds
Phytochemicals
Industrial Services (20)
Research Oriented Services (15)
Bio Re Inventors is offering its client an interactive platform for in-silico drug designing. This platform is equipped with essential modules to conduct early stage drug discovery. Our Experts is providing services on

⦁ Chemical Enrichment Analysis
⦁ Small Molecule Identification
⦁ Pocket Detection
⦁ Protein-Protein Docking
⦁ Protein-Peptide Docking
⦁ RNA-Ligand Interactions

⦁ Protein-Protein Interaction
⦁ Virtual Screening
⦁ Protein-Ligand Docking
⦁ Chemical Translation
⦁ GPCR ligand Interactions
⦁ Drug Pathways
etc...
We offer following customized services in various phases of drug discovery:

⦁ Database Development
⦁ Tools Development
⦁ Applications development

DISEASE DIAGNOSIS

Bio Re Inventors is developed advanced genomics and bioinformatics laboratory having collaborations with many hospitals and diagnostic laboratories. We used patient samples to identify disease from wet lab protocols and NGS data analysis. From DNA extraction to data interpretation, we understand your requirements in diagnostics and have created a technology solution with unprecedented accuracy.

WHAT WE OFFER

As experts in genomics data analyses, we can offer you the best analytical platform for treating your raw NGS data. This is simple, we validate your lab for an NGS test and you use our custom platform for routine diagnostics to achieve top analytical performance and shorten your turn around time.

GENETIC TESTS

Inherited diseases

Oncology

Diabetes

BIOCHEMICAL TESTS

Whole blood tests

Diabetes Tests

Kidney Tests

Lipid Tests

IMMUNOLOGY TESTS

Bacterial Infections

Viral Infections (HPV, HBV)

etc...

Advanced platform for Clinical Genomics is the platform of choice for clinicians to perform routine diagnostic testing. Our core technologies: Quality Analysis, Annotation, Alignment, Variant Analysis, Differential gene expression Analysis. The platform has most advanced artificial intelligence for Data-Driven Medicine. We processes and analyses raw genomic data to help hospitals better and faster diagnose patients across a broad range of diseases including oncology, metabolism, pediatrics, cardiology and hereditary cancers.

GENETIC RESOURCES IN AGRICULTURE

Bio Re Inventors agriculture genomic specialists is providing powerful tools to address the need to develop crop strains that can support increased food production while resisting pests and disease and reducing the environmental footprint, in terms of toxic chemicals and carbon emissions, of traditional farming.

The use of genomics for crop improvement promises to increase quality and yield of crops while using less fertilizer, pesticides and water. DNA tests based on the genome sequences of plants are making the selective breeding process more targeted and two to three times faster. In certain cases, genetic modification is creating plant strains with new properties that improve productivity and nutritional value.

Application

• Sequencing for SNP discovery
• Bioinformatics to select the best SNPs for genome wide association studies
• Identification of quantitative trait loci (QTL)
• Build high or medium density SNP arrays to create genomic models
• Build low density arrays and panels for marker assisted selection
• Use diagnostic tools to identify resistant or susceptible lines

SNP Genotyping
QTL Mapping
MAB
PRGM

A variation in a single base (Adenine, Thymine, Cytosine or Guanine) within a sequence of DNA. SNPs do not generally cause disease directly but some SNPs may affect an individual’s susceptibility to disease or the response to the drugs and treatments.

• Homogenous Detection
• Microarray genotyping
• Genome-wide selection
• Determining genetic merit
• Identification of QTLs
• Comparative genetic studies
etc...


GENETIC RESOURCES IN ANIMAL RESEARCH

Genomics can be used to speed up the genetic improvement of livestock traits, such as milk yield, meat quality and reproductive life. The process is fairly simple: we can use DNA markers that are linked to the desired traits to identify the highest potential animals, and select those for production and breeding. This type of genomic selection has rapidly become a key strategy for breeders and producers to reduce costs and increase productivity of their herds across a range of species.

Application

• Sequencing for SNP discovery
• Bioinformatics to select the best SNPs for genome wide association studies
• Identification of quantitative trait loci (QTL)
• Build high or medium density SNP arrays to create genomic models
• Build low density arrays and panels for marker assisted selection
• Use diagnostic tools to identify resistant or susceptible lines

SNP Genotyping
QTL Mapping
Marker Assisted Breeding

A variation in a single base (Adenine, Thymine, Cytosine or Guanine) within a sequence of DNA. SNPs do not generally cause disease directly but some SNPs may affect an individual’s susceptibility to disease or the response to the drugs and treatments.

• Homogenous Detection
• Microarray genotyping
• Genome-wide selection
• Determining genetic merit
• Identification of QTLs
• Comparative genetic studies
etc...

CLASSIFYING MICROBES IN PATHOGENIC & NONPATHOGENIC

Bio Re Inventors metagenomic specialists have designed gene identification from microbial pathogens. The technology and pipeline has robustness, reliability, and portability of molecular sequence-based data for phylogenetic assessments and for characterization of previously unrecognized pathogens, coupled with technology developments, recommend genomic approaches for both research and routine clinical applications

Service Provided: Targeted amplification, sequencing and bioinformatics. If you perform the amplification, we will accept those amplicons for sequencing and/or bioinformatics analysis.

Data Analysis

• De novo assembly
• BlastX
• Gene Prediction
• 16S rDNA or other housekeeping genes
• Function assignment to each gene candidate
• Constructing metabolic pathways
• Statistical analysis of two or more meta-genomic samples

NEXT GENERATION GENE IDENTIFICATION TECHNOLOGY

Bio Re Inventors providing services on Next generation sequence Data Analysis. Our Scientific research team helps its customers with a wide array of sequencing data that would cut down on the time spent on research data processing. Bio Re Inventors aims to transform agriculture, medicine and life science research through genomics and functional genomics approaches by reducing the gap between academic research and technology innovation through partnership and alliances. We provide standard bioinformatics analysis support. Our Ph.D.-level Project Management team is available to consult with you at every step of your project, including free post-delivery support.

100% Accuracy Results | Highly Confidential

SERVICE AREAS

Human
Animal
Plants
Microbes


TECHNOLOGY PLATFORMS
• Illumina (HiSeq/NextSeq/MiSeq)
• Ion Torrent
• Sanger Sequencer
• Genome resequencing analysis | Genome de novo analysis
• Exome analysis | De novo Transcriptome analysis
• Reference based Transcriptome analysis | ChIp-Seq

Feel Free To Fill Our Form
SNP
DNA
Query
PREDICTING GENE EXPRESSION ON DISEASES

Bio Re Inventors Genomic Group has vast experience on genomics to predict novel genes and their expression levels. Our group of statisticians and software engineers is designed customized gene chips to identify the diseases and developing customized databases. We are supporting our clients to design customized gene chip preparation, data mining, data analysis, and Interpretation and Report generation.

100% Accuracy Results | Highly Confidential

Expert on R & Bioconductor,


Microarray Algorithms Implementation
Microarray Image Analysis
Microarray Data Analysis
R & Bioconductor


Bio Re Inventors genomics team has helped many clients to uncover biological insights from their data. We have extensive experience in analyzing genomics data, whether for preclinical research & development or data generated from clinical trials.

• Preprocess of Image | Post Process of Image | Image enhancement
• filtering & deblurring | segmentation & morphology | feature extraction
• Graphical Interpretation | Data Storage etc...

We offer following customized services in various phases of Microarray Analysis:

• Database Development
• Tools Development
• Applications development

Protein modelling and rational drug designing are now a popular technique used for increasing the speed of drug designing process. This was made possible by the availability of many protein structures which helped in developing tools to understand the structure-function relationships, automated docking, and virtual screening. The goal is to identify a key drug target based on a thorough understanding of regulatory networks and metabolic pathways and to design a highly specific drug based on the known three-dimensional (3D) structure of that target.

This is a special type of service which we have introduced in order to accelerate the process of vaccine development for different diseases. Apart from vaccine design Immunoinformatics can be used in different ways like Development of biological therapeutics, Analysis of immunogenetics, Predicting protein allergenicity, Design of immuno-therapeutic drugs.

It is a new and very unique technology of gene editing, which can be used in various fields for research and R & D works by different Research Institutes and Diagnostics lab. This technology can be used for curing different diseases at genetic level

The vast range of in-silico data mining that are available in life sciences research hold much promise towards aiding the drug discovery process as well as to fully realize this opportunity, computational scientists must consider the practical issues of data integration and identify how best to apply these resources scientifically.

• Genome Variants and Protein Modifications
• Therapeutic Target Discovery
• Drug Target Discovery
• On/Off Target Discovery
• Diagnostics
• Micro biome
• Metabolome
• Transcriptome

Once a genome is sequenced, all of the sequencings must be analyzed to understand what they mean. Critical to annotation is the identification of the genes in a genome, The structure of the genes, and the proteins they encode. Once a genome is annotated, further work is done to understand how all the annotated regions interact with each other.

• Identify relationships between genes and proteins or diseases
• Cite connections between genes or proteins and chemicals
• Extract bind/inhibit chemicals from proteins or genes
• Examine SNP information and association with disease
• Find bind/inhibit compounds and therapeutic targets from associated disease
• Gene expression prioritization from RNAseq data
• Search known functions of miRNA and extract genes and related diseases
• Identify chemical compounds associated with gene & amino acid mutations
• Predict target proteins and activity values by mining similarities between protein and chemical structures
• Examine pathways associated with significant genes and proteins

The powerful technologies allow the analysis of whole genomes on one or two arrays. Off the shelf arrays are available for many genomes, including Human, Mouse, Rat, Arabidopsis, C. Elegans, E. coli, yeast, P. aeruginosa, Drosophila. Over 20 kinds of annotation including: genes (ontology, pathways), proteins, diseases, domains, ligands, and compounds. Prioritization of genes and proteins can be executed from a variety of directions.

• Statistical processing from expression values
• Conversion and active compound information from proteins
• Inhibitor compounds and inhibitory active compounds
• Assay summary of the target listed by endpoint, such as Ki/IC50
• Positive control chemicals